Iron Acquisition by the Genus Mycobacterium: History, by B. Rowe Byers

By B. Rowe Byers

Iron Acquisition through the Genus Mycobacterium summarizes the early facts for the need of iron in mycobacteria and the invention of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is defined.  The genes up to now pointed out as crucial for iron acquisition and upkeep of infection by means of pathogenic mycobacteria are discussed.  the capability position of siderocalin in iron amassing via M. tuberculosis is featured. simply because new medicines for M. tuberculosis are wanted, this short additionally emphasizes the layout of antibiotics that intrude with siderophore biosynthesis and using siderophore analogs and/or conjugates.

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