The Epothilones: An Outstanding Family of Anti-Tumor Agents: by Johann H. Mulzer,Karl-Heinz Altmann,Gerhard Höfle,Rolf

By Johann H. Mulzer,Karl-Heinz Altmann,Gerhard Höfle,Rolf Müller,Kathrin Prantz

Epothilones have bought strange awareness during the last ten years. they're novel antitumor medicinal drugs which a great deal like their predecessor paclitaxel (Taxol) act through microtubule stabilization. compared to paclitaxel and a few replacement medications with an analogous mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have major merits, mainly very excessive task within the nanomolar diversity and coffee susceptibility in the direction of multidrug resistance. Epothilone B and a number of other derivatives thereof are in section I-III medical trials; one among them (ixabepilone, BMS) is already out there, others are meant to seem out there within the close to destiny. All obviously happening epothilones were remoted from Sorangium cellulosum; their antitumor motion is traced again to the stabilization of microtubules. consequently, the formation of the mitototic spindle is illegal and the telephone undergoes apoptosis.

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