The Pauson-Khand Reaction: Scope, Variations and by Ramon Rios Torres

By Ramon Rios Torres

The Pauson-Khand response is a crucial response within the box of natural chemistry. It consists of the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to supply cyclopentenones.   the significance of this response originates from its excessive worth in remodeling uncomplicated elements into the synthetically helpful cyclopentenone unit, during which a excessive measure of molecular complexity might be accomplished in one step, with amazing stereochemical and regiochemical keep an eye on.

The Pauson-Khand Reaction investigates the character and plenty of diversifications of this reaction.

Topics lined include: 

  • the mechanisms of Pauson‐Khand-type reactions
  • non chiral  intramolecular and intermolecular models of Pauson‐Khand reactions
  • asymmetric Pauson‐Khand response utilizing chiral auxiliaries
  • the enantioselective Pauson‐Khand reaction
  • Pauson‐Khand reactions catalysed through metals except cobalt
  • unconventional Pauson‐Khand reactions
  • the Pauson‐Khand response in overall synthesis

Presenting a finished assessment of this primary response, The Pauson-Khand Reaction will discover a position at the bookshelves of any natural or organometallic chemist. 

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